Antiviral Resveratrol, Knotweed (Sourweed) & Covid-19Unity Consciousness #2599

(9azzzv of 11)

Japanese Knotweed (Sourweed) has been discussed. Resveratrol has not been.
The antiviral benefits of Knotweed have been discussed.
The antiviral effects of many plants have been discussed.
Food as medicine has been discussed.
Alternative approaches to dealing with coronavirus have been discussed.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8289713/

2021 Jul 20
Resveratrol (RES) is a polyphenol with increasing interest for its inhibitory effects on a wide variety of viruses.
Polyphenols have been of interest to researchers around the world as potential antiviral agents due to their low toxicity profile and high abundance in nature. So far, more than 10,000 polyphenols have been identified, among which resveratrol (RES) exhibits increasing attention. In recent decades, a wide variety of active phytochemicals exhibited antiviral activities. RES is mainly found in red wine, skin of red grapes, berries, dark chocolate peanuts, and seeds. Polyphenols were postulated to have antiviral properties. In this sense, Reserveratrol exerted inhibitory effects against influenza A, herpes simplex type 1, rotavirus, Middle East respiratory syndrome, severe acute respiratory syndrome coronavirus-2, dengue (DENV) and Zika (ZIKV) viruses.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848669/

2016 Apr
Resveratrol, a naturally occurring plant polyphenol found in grapes, is the principal biologically active component in red wine. Clinical studies have shown that resveratrol, due to its potent anti-oxidant and anti-inflammatory properties, are cardio-protective, chemotherapeutic, neuroprotective [thus likely beneficial in neurological disorders such as dementia syndrome], and display anti-aging effects. Oxidative stress and inflammation play a critical role in the initiation and progression of age-related ocular diseases (glaucoma, cataract, diabetic retinopathy and macular degeneration) that lead to progressive loss of vision and blindness. In vitro and in vivo (animal model) experimental studies performed so far have provided evidence for the biological effects of resveratrol on numerous pathways including oxidative stress, inflammation, mitochondrial dysfunction, apoptosis, pro-survival or angiogenesis that are implicated in the pathogenesis of these age-related ocular disorders.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5435979/

2017
The Repeated Administration of Resveratrol Has Measurable Effects on Circulating T-Cell Subsets in Humans
Preclinical studies have shown that resveratrol exerts immunomodulatory effects with potential clinical value in the amelioration of autoimmune disorders and cancer prevention; however, little is known about the in vivo effects of this naturally occurring polyphenol on human immune cells. We assessed the effects of repeated doses of resveratrol (1000 mg/day for 28 days) on circulating immune cells in healthy Japanese individuals. Resveratrol was safe and well tolerated and was associated with significant increases in the numbers of circulating γδ T cells and regulatory T cells and resulted in small, yet significant, decreases in the plasma levels of the proinflammatory cytokines TNF-α and MCP-1 and a significant increase in the plasma antioxidant activity compared with the corresponding antioxidant baseline activity and with that in four control individuals. In in vitro studies, resveratrol significantly improved the growth of γδ T cells and regulatory T cells. These findings demonstrate that resveratrol has some clear biological effects on human circulating immune cells. Further studies are necessary to interpret the long-term immunological changes associated with resveratrol treatment.

Introduction: Resveratrol is a naturally occurring polyphenolic stilbene that is produced by certain plants in response to various stress stimuli including, microbe infection, ultraviolet radiation, and injury. As a plant-derived substance, resveratrol can be found in various dietary sources including grapes, berries, peanuts, and red wine. Another important source of resveratrol is the Japanese knotweed, which has long been used in Japan and China as a traditional herbal remedy

https://www.livestrong.com/article/34699-negative-effects-resveratrol/

Drug Interactions
Resveratrol may interact with several medications. The Linus Pauling Institute reports that resveratrol may inhibit cytochrome 3A4, which may cause interactions with HMG-CoA reductase inhibitors, calcium channel agonists, anti-arrhthmic agents, HIV protease inhibitors, immunosuppressants, antihistamines, and erectile dysfunction medications. In addition, the natural blood pressure-lowering and anti-coagulant effects of resveratrol may cause interaction with blood pressure, anti-platelet, and anticoagulant medication, as well as NSAIDs such as aspirin and ibuprofen.
[To this I say, it might be true for resesveratrol medication, but not true for resveratrol consumed in food]

https://pubmed.ncbi.nlm.nih.gov/30741437/

2019 Sept
Resveratrol is a polyphenolic nutraceutical that exhibits pleiotropic activities in human subjects. The efficacy, safety, and pharmacokinetics of resveratrol have been documented in over 244 clinical trials, with an additional 27 clinical trials currently ongoing. Resveratrol is reported to potentially improve the therapeutic outcome in patients suffering from diabetes mellitus, obesity, colorectal cancer, breast cancer, multiple myeloma, metabolic syndrome, hypertension, Alzheimer's disease, stroke, cardiovascular diseases, kidney diseases, inflammatory diseases, and rhinopharyngitis. The polyphenol is reported to be safe at doses up to 5 g/d, when used either alone or as a combination therapy. Although the clinical utility of resveratrol is well documented, the rapid metabolism and poor bioavailability have limited its therapeutic use. In this regard, the recently produced micronized resveratrol formulation called SRT501, shows promise. This review discusses the currently available clinical data on resveratrol in the prevention, management, and treatment of various diseases and disorders.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164842/

2018 Sept
Resveratrol (3,5,4′-trihydroxy-trans-stilbene) belongs to polyphenols’ stilbenoids group, possessing two phenol rings linked to each other by an ethylene bridge. This natural polyphenol has been detected in more than 70 plant species, especially in grapes’ skin and seeds, and was found in discrete amounts in red wines and various human foods. It is a phytoalexin that acts against pathogens, including bacteria and fungi. As a natural food ingredient, numerous studies have demonstrated that resveratrol possesses a very high antioxidant potential. Resveratrol also exhibit antitumor activity, and is considered a potential candidate for prevention and treatment of several types of cancer. Indeed, resveratrol anticancer properties have been confirmed by many in vitro and in vivo studies, which shows that resveratrol is able to inhibit all carcinogenesis stages (e.g., initiation, promotion and progression). Even more, other bioactive effects, namely as anti-inflammatory, anticarcinogenic, cardioprotective, vasorelaxant, phytoestrogenic and neuroprotective have also been reported. Nonetheless, resveratrol application is still being a major challenge for pharmaceutical industry, due to its poor solubility and bioavailability, as well as adverse effects.